Characters like Omega Red bring back fond memories of what I consider my own personal "golden age" of comics. Back then, Wolverine had constant battles with Sabretooth, the Silver Samurai, and Omega Red. Of course Maverick and Lady Deathstrike would make their occasional appearances too. Amazing work dude. Looking at this brought back a nostalgia bomb of memories.
According to the wiki, he died in Wolverine Origins #39 after being stabbed in the heart with the Muramasa blade by Wolverine. All I know is that I have the X-MEN #4 comic that Jim Lee first introduced him in and it was a very sweet issue in my memory.